Salicylic acid (from Latin salix, willow tree, from the bark of which the substance used to be obtained) is a mono hydroxy benzoic acid, a type of phenolic acid and a beta hydroxy acid. This colorless crystalline organic acid is widely used in organic synthesis and functions as a plant hormone. It is derived from the metabolism of salicin. In addition to being an important active metabolite of aspirin (acetylsalicylic acid), which acts in part as a prodrug to salicylic acid, it is probably best known for its use in anti-acne treatments. The salts and esters of salicylic acid are known as salicylates.
1. Salicylic acid is a beta-hydroxy acid with keratolytic and anti inflammatory activity. It helps dissolve the top layer of stratum corneum cells, improving the look and feel of the skin.
2. Salicylic acid is known for its ability to ease aches and pains and reduce fevers. These medicinal properties, particularly fever relief, have been known since ancient times, and it is used as an anti-inflammatory drug.
3.Salicylic acid used as complexing indicator and preservative.
4.Salicylic acid is an important raw material of medicine, spices, dyes, rubber auxiliaries and other fine chemicals.
Salicylic acid (from Latin salix, willow tree, from the bark of which the substance used to be obtained) is a mono hydroxy benzoic acid, a type of phenolic acid and a beta hydroxy acid. This colorless crystalline organic acid is widely used in organic synthesis and functions as a plant hormone. It is derived from the metabolism of salicin. In addition to being an important active metabolite of aspirin (acetylsalicylic acid), which acts in part as a prodrug to salicylic acid, it is probably best known for its use in anti-acne treatments. The salts and esters of salicylic acid are known as salicylates.
1. Salicylic acid is a beta-hydroxy acid with keratolytic and anti inflammatory activity. It helps dissolve the top layer of stratum corneum cells, improving the look and feel of the skin.
2. Salicylic acid is known for its ability to ease aches and pains and reduce fevers. These medicinal properties, particularly fever relief, have been known since ancient times, and it is used as an anti-inflammatory drug.
3.Salicylic acid used as complexing indicator and preservative.
4.Salicylic acid is an important raw material of medicine, spices, dyes, rubber auxiliaries and other fine chemicals.
Item | Specifications | Results | |
Characters | A white, crystalline powder or white or colorless, acicular crystals, slightly soluble in water, freely soluble in ethanol (96 per cent), sparingly soluble in methylene chloride. | Complies | |
Identification A | Melting point158 °C to 161 °C | 160.2°C | |
Identification B | The IR spectrum of sample complies with salicylic acid CRS | Complies | |
Appearance of solution | Solution is clear and colorless | Solution is clear and colorless | |
Particle size | 100-120mesh | Complies | |
Related substances | 4-hydroxybenzoic acid | ≤0.1% | 0.03% |
4-hydroxyisophthalic acid | ≤0.05% | 0.02% | |
Phenol | ≤0.02% | 0.01% | |
Other impurities | ≤0.05% | 0% | |
Total impurities | ≤0.2% | 0.06% | |
Chloride | NMT100ppm | <100ppm | |
Sulfate | NMT200ppm | <200ppm | |
Heavy metals | NMT20ppm | <20ppm | |
Loss on drying | NMT0.5% | 0.26% | |
Sulphated ash | NMT0.1% | 0.06% | |
Assay(dried substance) | ContainsC7H6O399.0%-100.5% | 99.5% | |
Conclusion | The results conforms with EP 7.0 standards |
Item | Specifications | Results | |
Characters | A white, crystalline powder or white or colorless, acicular crystals, slightly soluble in water, freely soluble in ethanol (96 per cent), sparingly soluble in methylene chloride. | Complies | |
Identification A | Melting point158 °C to 161 °C | 160.2°C | |
Identification B | The IR spectrum of sample complies with salicylic acid CRS | Complies | |
Appearance of solution | Solution is clear and colorless | Solution is clear and colorless | |
Particle size | 100-120mesh | Complies | |
Related substances | 4-hydroxybenzoic acid | ≤0.1% | 0.03% |
4-hydroxyisophthalic acid | ≤0.05% | 0.02% | |
Phenol | ≤0.02% | 0.01% | |
Other impurities | ≤0.05% | 0% | |
Total impurities | ≤0.2% | 0.06% | |
Chloride | NMT100ppm | <100ppm | |
Sulfate | NMT200ppm | <200ppm | |
Heavy metals | NMT20ppm | <20ppm | |
Loss on drying | NMT0.5% | 0.26% | |
Sulphated ash | NMT0.1% | 0.06% | |
Assay(dried substance) | ContainsC7H6O399.0%-100.5% | 99.5% | |
Conclusion | The results conforms with EP 7.0 standards |