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(PQQ)Pyrroloquinoline Quinone Disodium Salt(PQQ)
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(PQQ)Pyrroloquinoline Quinone Disodium Salt(PQQ)

  • API016

  • 99%

  • HPLC

  • Dark red powder

  • 122628-50-6

Availability:

Pqq pyrroloquinoline quinone disodium salt Overview


Product Name:

Pyrroloquinoline quinone (PQQ)

CAS NO:

122628-50-6/ 72909-34-3

Molecular Formula:

C14H4N2Na2O8/ C14H6N2O8

Molecular Weight

374.17/ 330.21

Specification:

99%

Appearance:

Reddish orange to Reddish Brown Fine Powder.

Test Method:

HPLC

Pyrroloquinoline quinone (PQQ), also known as Methoxy Platinum, is a redox cofactor. It exists in the soil, kiwifruit, foods, and human breast milk. Directly speaking, the word “pyrroloquinoline quinone” is a little bit awkward, so most people prefer to use the abbreviation PQQ. The scientific journal Nature published a paper by Kasahara and Kato in 2003, which considered PQQ is a new vitamin. However, after further about pyrroloquinoline quinone research, the researchers determined that although it has some vitamin-like properties, it is only a related nutrient. PQQ can be used as a co-factor or enzymatic promoter in the redox process. PQQ has a specific antioxidant effect due to its participation in redox

PQQ


Pyrroloquinoline Quinone food sources

PQQ naturally exists in most vegetable foods, fruits, and vegetables (trace), and relatively high levels of PQQ can be detected in fermented soybean products, such as kiwifruit, lychee, green beans, tofu, rapeseed, mustard, green tea (camellia), green pepper, spinach, etc.

Pyrroloquinoline quinone (PQQ)

G. Haug found that it was the third redox cofactor in bacteria after nicotinamide and flavin (although he assumed it was naphthoquinone). Anthony and Zatman also found unknown redox cofactors in ethanol dehydrogenase. In 1979, Salisbury and his colleagues as well as Duine and their colleagues extracted this pseudo base from methanol dehydrogenase of dinoflagellates and identified its molecular structure. Adachi and his colleagues found that Acetobacter also contains PQQ.


Mechanism of action of Pyrroloquinoline Quinone

Pyrroloquinoline quinone (PQQ) is a small quinone molecule, which has a redox effect, can reduce oxidant (antioxidant); it then is recovered into the active form by glutathione. It seems relatively stable because it can undergo thousands of cycles before depletion, and it is new because it is related to the protein structure of cells (some antioxidants, main carotenoids such as beta-carotene and astaxanthin, are located in specific areas of cells, where they play more antioxidant roles proportionally). Because of proximity, PQQ seems to play a role near proteins such as carotenoids on cell membranes.

mitochondrion function

These redox functions can alter protein functions and signal transduction pathways. Although there are many promising studies in vitro (outside living models), some promising results of PQQ supplementation are mainly related to altering some signal transduction pathways or their benefits to mitochondria. (Produce more and improve efficiency).

It’s a coenzyme in bacteria (so for bacteria, it’s like B-vitamins), but it doesn’t seem to extend to humans. Since this does not apply to humans, a 2003 article in Nature, a scientific journal, argues that the idea that PQ is a vitamin compound is outdated and at best considered as a “vitamin-like substance.”

Perhaps most notable is the effect of PQQ on mitochondria, which provide energy (ATP) and regulate cell metabolism. Researchers have extensively observed the impact of PPQ on mitochondria and found that PQQ can increase the number of mitochondria and even improve the efficiency of mitochondria. This is an important reason why PPQ is so useful. Enzymes containing PQQ are known as glucose dehydrogenase, a quinoa protein that is used as a glucose sensor.

PQQ


Benefits of Pyrroloquinoline Quinone

Having the mitochondria at their best is so essential for a healthy life that you can experience many benefits while taking ppq. Here are some of the most noteworthy about pyrroloquinoline quinone benefits.

Increasing Cell Energy

Because mitochondria generate energy for cells, and PQQ helps mitochondria work more effectively, energy in cells increases as a whole; this is the Pyrroloquinoline Quinone mitochondrial mechanism. Unused cellular energy is diverted to other parts of the body. If your body lacks power all day, or you feel tired or drowsy, then the increased strength of PPQ is vital to you. One study found that after taking PQQ, subjects with reported energy problems had significantly lower levels of fatigue. If you are looking for something to increase your energy, PQQ may help with that.

Preventing cognitive decline

With the development of science, scientists have found that nerve growth factor (NGF) can grow and recover.  At the same time, PQQ has been shown to have a positive effect on NGF and to increase nerve growth by 40 times. NGF is essential for the formation and maintenance of new neurons, and it can restore damaged neurons that may inhibit cognitive function. Neurons are cells that transmit information, so our brains can communicate between themselves and other parts of the body. Improving the quality and quantity of neurons can improve cognition. Therefore, PQQ has short-term improvement.

Supporting cardiovascular health

Pyrroloquinoline quinine provides antioxidant and mitochondrial support. Studies have shown that both PQQ and CoQ10 support myocardial function and proper cellular oxygen utilization. Pyrroloquinoline quinone prevents oxidative stress through its rejuvenation

Other Efficacy:

Except for the three main benefits listed above, PQQ offers other less well-known benefits. PQQ may play a role in alleviating body inflammation, better your sleep and can improve fertility, but more research is needed to draw definitive conclusions. As research progresses, more benefits of taking PQQ may be discovered.

The dosage of Pyrroloquinoline Quinone

At present, no government or WHO has stipulated the pyrroloquinoline quinone dosage. However, some individuals and institutions have done many biological tests and human tests on the optimal dosage of pyrroloquinoline quinone powder. Through observing and comparing the physical performance of the subjects, it is concluded that the optimal dosage of PQQ is 20 mg-50 mg. Always refer your doctor if there are any questions pending. Such as biopqq pyrroloquinoline quinone disodium salt.

Side effects of PQQ

Since 2009, dietary supplements containing PQQ Na 2 have been commercialized in the United States after formal notification by the Food and Drug Administration (FDA), and no adverse reactions have been reported. If you want to add pyrroloquinoline quinone supplements to your diet, it’s important to remember one thing. Since it does not require too much PQQ to produce an effect, most doses are kept in a minimum range. Therefore, most people do not have to worry about any Pyrroloquinoline Quinone side effects. (That’s you bought pyrroloquinoline quinone PQQ supplement from the market)



Pqq pyrroloquinoline quinone disodium salt COA I 

Pyrroloquinoline Quinone disodium salt (Natural)

Product and Batch Information

Product Name:

Pyrroloquinoline Quinone disodium salt (Natural)

Country of Origin:

P.R. China

CAS No.:

122628-50-6

Molecular Weight:

374.17

Molecular Formular:

C14H4N2O8 .2Na

Batch:

HB-PQQDS-220218

Manufacture Date:

Feb 18, 2022.

Expiry Date:

Feb 17, 2024.

Item

Specification

Result

Test Method

Active Ingredients

Assay(%, On Dried base)

NLT99.0%

99.75%

HPLC

PQQ Content (%,On Dried base)


87.4%-88%


87.78%


USP

Physical Control

Appearance

Fine Powder

Complies

Visual

Color

Henna

Complies

Visual

Identification

Positive

Complies

IR

Water

NMT 12.0%

10.02%

GC

Chemical Control

Heavy Metals

NMT 10PPM

Conforms

Atomic Absorption

Arsenic(As)

NMT 1.5PPM

Conforms

Atomic Absorption

Mercury(Hg)

NMT 0.2PPM

Conforms

Atomic Absorption

Cadmium(Cd)

NMT 0.3PPM

Conforms

Atomic Absorption

Lead(Pb)

NMT 1.0PPM

Conforms

Atomic Absorption

Solvents Residual

Meeting USP Standard

Conforms

GC

Microbiological Control

Total Plate Count

1,000cfu/g Max

Conforms

AOAC

Yeast & Mold

100cfu/g Max

Conforms

AOAC

Enterobacteriaceae

100cfu/g Max

Conforms

AOAC

E.Coli

Negative/10g

Negative

AOAC

Salmonella sp.

Negative/25g

Negative

AOAC

Staph Aureus

Negative/10g

Negative

AOAC

Packing and Storage

Ingredient

it is a 100% natural PQQ and not a synthetic one

Packing

Pack in paper-drums and two plastic bags inside. 11Kg/Drum

Storage

Store in a well-closed container away from moisture and direct sunlight.

Shelf Life

2 years if sealed and stored properly.


COA II 

Pyrroloquinoline Quinone Acid

Product and Batch Information

Product Name:

Pyrroloquinoline Quinone Acid

Country of Origin:

P.R. China

CAS No.:

72909-34-3

Batch:

HB-PQQA-210903

Molecular Formular:

C14H6N2O8

Molecular Weight:

330.21

Manufacture Date:

Sep 03, 2021.

Expired  Date:

Sep 02, 2023.

Item

Specification

Result

Test Method

Active Ingredients

ssay(w/w ,on dried base)

98.0% Min

99.50%

HPLC

Physical Control

Appearance

Fine  Powder

Complies

Visual

Color

Reddish orange to Reddish Brown

Complies

Visual

Taste

Sour

Complies

Organoleptic

Identification

Positive

Complies

IR

Loss on Drying

12% Max

5.80%

USP

Chemical Control

Heavy Metals

NMT 10ppm

Conforms

Atomic Absorption

Arsenic (As)

NMT 1.0ppm

Conforms

Atomic Absorption

Mercury(Hg)

NMT 0. 1ppm

Conforms

Atomic Absorption

Cadmium(Cd)

NMT 1.0ppm

Conforms

Atomic Absorption

Lead (Pb)

NMT 0.5ppm

Conforms

Atomic Absorption

Microbiological Control

Total Plate Count

1000cfu/g Max

Conforms

AOAC

Yeast & Mold

100cfu/g Max

Conforms

AOAC

E.Coli

Negative

Conforms

AOAC

Salmonella

Negative

Conforms

AOAC

Packing and Storage

Packing

Pack in alumium fosil bag and two plastic-bags inside.  1.0Kg/Bag

Storage

Store in a well-closed container away from moisture and direct sunlight.

Shelf Life

2 years if sealed and stored properly.



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